Jon Takemoto

Publications - Abstracts

• Takemoto, J.Y, (2007). Probing the pore geometry of the syringomycin E channel with polyethylene glycols. Biophys. J. *
• Chang, C.W, Elchert, B., Hui, Y., Li, J.K, Wang, J., Rai, R., Takemoto, J.Y, (2003). Synthetic glycorandomization of ring III pyranose of pyranmycin.. Abstracts of Papers of the American Chemical Society *
• Blasko, K., Grilley, M.M, Takemoto, J.Y, (1999). Sphingomyelin is required for syringomycin E action on human red blood cell membrane permeability. Biophysical Journal
• Takemoto, J.Y, (1996). Production, purification and in vitro antifimgal activity of syringostatin -A, a new antifungal agent produced by Pseudomonas syringae pv. syringae. Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A12 (abstract) *
• Takemoto, J.Y, (1996). Role of secondary metabolites in biological control by Pseudomonas syringae pv. syringae strains ESC-10 and ESC-11. Abstracts, 8th International Congress of Molecular Plant-Microbe Interactions, Knoxville, TN, July 14-20 (abstract) *
• Takemoto, J.Y, (1996). The influence of sterol and phospholipid structure on the properties of syringomycin E-induced channels. Biophys. J. 70(2):Al94 (Abstract) *
• Takemoto, J.Y, (1996). Voltage-gated ion channels formed by syringomycin E in planar lipid bilayers. Biophys. J. 70(2):A194 (Abstract) *
• Takemoto, J.Y, (1995). Function of syringomycin response gene, SYR2, in yeast sterol metabolism. Abstracts, 95th Ann. Meet. Amer. Soc. Microbiol. A95 *
• Takemoto, J.Y, (1995). In vitro activity of syringomycin E, a new antifungal produced by Pseudomonas syringae pv. syringae. Abstracts, Ann. Mtg., Intrmntn. Branch Amer. Soc. Microbiol. 43:B10 *
• Takemoto, J.Y, (1995). In vitro antifungal and fungicidal activity of a cyclic lipodepsipeptide, syringomycin E. Abstracts, 35th Interscience Conf. Antimicrob. Agents and Chemotherapy, F103 *
• Takemoto, J.Y, (1995). Role of H2O2 in Syringomycin Action Against Yeast. Abstracts, Ann. Mtg., Intrmntn. Branch, Amer. Soc. Microbiol. 43:B9 *
• Takemoto, J.Y, (1994). Influence of cellular sterol composition on syringomycin inhibition of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A95 *
• Takemoto, J.Y, (1994). Isolation and characterization of novel syringomycin-resistant mutants of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A94 *
• Takemoto, J.Y, (1993). Antifungal properties of Pseudomonas syringae pv. syringae strain M1 from wheat seed coat. Abstracts, Ann. Mtg., Inter. Branch, Amer. Soc. Microbiol. 41:A4 *
• Takemoto, J.Y, (1993). Cloning and characterization of SYR2: A novel gene of Saccharomyces cerevisiae involved in the response to syringomycin. Abstracts, Ann. Mtg., Interm. Branch, Amer. Soc. Microbiol. 41:A.5 *
• Takemoto, J.Y, (1993). Identification of gene, SYR1, involved in syringomycin inhibition of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Interm. Branch, Amer. Soc. Microbiol. 41:A3 *
• Takemoto, J.Y, (1993). Properties of Syringomycin-Resistant Mutants of Saccharomyces Cerevisiae. Abstracts *
• Takemoto, J.Y, (1992). Saccharomyces cerevisiae genes involved in the response to Pseudomonas syringae phytotoxin, syringomycin. Phytopathology 82:1126 *

Publications - Books & Book Chapters

Book Chapters

• Malev, V.V, Ostroumova, O.S, Schagina, L.V, Takemoto, J.Y, (2008). Voltage-dependent ion channels induced by cyclic lipodepsipeptides in planar lipid bilayers: structure, properties, and resemblance to native channels: Planar Lipid Bilayers and Liposomes volume 6. Academic Press
• Takemoto, J.Y, Brand, J.G, Kaulin, Y.A, Malev, V.V, Schagina, L.V, Blasko, K., Menestrina, G., Serra, M.D, Lazarovici, P., (2003). The syringomycins: lipodepsipeptide pore formers from plant bacterium, Pseudomonas syringae. Pore Forming Peptides and Protein Toxins
• Hama, H., Takemoto, J.Y, DeWald, D.B, (1999). Analysis of phosphoinositides in protein trafficking. In Methods: A Companion to Methods in Enzymology
• Takemoto, J.Y, Verma, D.P, (1992). Bacterial phytotoxin syringomycin and its action on host membranes. Molecular Signals in Plant-Microbe Communications
• Bachmann, R.C, Takemoto, J.Y, (1989). Structure of Syringomycin. A Progress Report. p. 359-361. IN: A. Graniti, R.D. Durbin and A. Ballio (eds.), Phytotoxins and Plant Pathogenesis. Springer-Verlag, Berlin-Heidelberg
• Takemoto, J.Y, Giannini, J.L, Vassey, T., Briskin, D.P, (1989). Syringomycin effects on plasma membrane Ca+2 transport, p. 167-175. IN: A. Graniti, R. D. Durbin & A. Ballio (eds.), Phytotoxins & Plant Pathogenesis

* Has not been peer reviewed

Publications - Fact Sheets

* Has not been peer reviewed

Publications - Curriculum

* Has not been peer reviewed

Publications - Journal Articles

Academic Journal

• Subedi, Y.P, AlFindee, M.N, Takemoto, J.Y, Chang, C.T, (2018). Antifungal amphiphilic kanamycins: new life for an old drug. MedChem Comm, doi: DOI: 10.1039/c8md00155c
• AlFindee, M.N, Zhang, Q., Subedi, Y.P, Shrestha, J.P, Kawasaki, Y., Grilley, M.M, Takemoto, J.Y, Chang, C.T, (2018). One-step synthesis of carbohydrate esters as antibacterial and antifungal agents. Bioorganic & Medicinal Chemistry, 26:3, 765-774.
• AlFindee, M.N, Zhang, Q., Subedi, Y.P, Shrestha, J., Kawasaki, Y., Grilley, M.M, Takemoto, J.Y, Chang, C.T, (2018). One-step Synthesis of Carbohydrate Esters as Antibacterial and Antifungal Agents. Bioorg. Med. Chem., 26, 765.
• Takemoto, J.Y, Wegulo, S., Yuen, G.Y, Stevens, J.A, Jochum, C.C, Chang, C.T, Kawasaki, Y., Miller, G.A, (2018). Suppression of wheat fusarium head blight by novel amphiphilic aminoglycoside fungicide K20 . Fungal Biology, in press, doi: doi.org/10.1016/j.funbio.2017.12.001
• Xu, F., Napan, K., Zhang, S., Gladwin, T., Takemoto, J.Y, Zhan, J., (2017). New insights into pradimicin biosynthesis revealed by two O-methyltransferases. Bioorg Med Chem Lett, 27:15, 3499-3502.
• Shrestha, J., Colman, B., Kawasaki, Y., Nziko, V., Subedi, Y., Takemoto, J.Y, Chang, C.T, (2017). Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens. Eur. J. Med. Chem., 126, 596.
• Alder-Rangel, A., Bailao, A.M, da Cunha, A.F, Soares, C.M, Wang, C., Bonatto, D., Dadachova, E., Hakalehto, E., Eleutherio, E.C, Fernandes, E.K, Gadd, G.M, Braus, G.H, Braga, G.U, Goldman, G.H, Malavazi, I., Hallsworth, J.E, Takemoto, J.Y, Fuller, K.K, Selbmann, L., Corrochano, L.M, von Zeska Kress, Marcia R., , Bertolini, M.C, Schmoll, M., Pedrini, N., Loera, O., Finlay, R.D, Peralta, R.M, Rangel, D.E, (2017). The second international symposium on fungal stress: ISFUS. Fungal Biology, in press, doi: https://doi.org/10.1016/j.funbio.2017.10.011
• Zhang, Q., Alfindee, M.N, Shrestha, J.P, Vincent de Paul Nzuwah, N., Kawasaki, Y., Peng, X., Takemoto, J.Y, Chang, C.T, (2016). Divergent synthesis of three classes of antifungal amphiphilic kanamycin derivatives. Journal of Organic Chemistry, 81:22, 10651-10663.
• Kawasaki, Y., Nischwitz, C., Grilley, M.M, Jones, J., Brown, J.D, Takemoto, J.Y, (2016). Production and application of syringomycin E as an organic fungicide seed protectant against pythium damping-off. Journal of Phytopathology, 164:10, 801–810.
• Fosso, M., AlFindee, M.N, Zhang, Q., Nziko Vde, P., Kawasaki, Y., Shrestha, S.K, Bearss, J., Gregory, R., Takemoto, J.Y, Chang, C.W, (2015). Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues. J Org Chem, 80:9, 4398-411.
• Wood, J.L, Miller, C.D, Sims, R.C, Takemoto, J.Y, (2015). Biomass and phycocyanin production from cyanobacteria dominated biofilm reactors cultured using oilfield and natural gas extraction produced water. Algal Research, 11, 165-168.
• Shrestha, S.K, Grilley, M.M, Anderson, T., Dhiman, C., Oblad, J., Chang, C.T, Sorensen, K.N, Takemoto, J.Y, (2015). In vitro antifungal synergy between amphiphilic aminoglycoside K20 and azoles against Candida species and Cryptococcus neoformans. Med Mycol
• Zhang, Q., Peng, X., Grilley, M.M, Takemoto, J.Y, Chang, C.T, (2015). Using fluorogenic probes for the investigation of selective biomass degradation by fungi. Green Chem, 17, 1918-1925.
• Napan, K.L, Zhang, S., Anderson, T., Takemoto, J.Y, Zhan, J., (2015). Three enzymes involved in the N-methylation and incorporation of the pradimicin sugar moieties. Biorganic and Medicinal Chemistry Letters, 26:6, 1288-1291. doi: doi.org/10.1016/j.bmcl.2015.01.043
• Shrestha, S.K, Chang, C.T, Meissner, N., Oblad, J., Shrestha, J.P, Sorensen, K.N, Grilley, M.M, Takemoto, J.Y, (2014). Antifungal amphiphilic aminoglycoside K20: bioactivities and mechanism of action. Frontiers in Microbiology, 5:271, 1-12. doi: doi: 10.3389/fmicb.2014.00671
• Chang, C.T, Takemoto, J.Y, (2014). Antifungal amphiphilic aminoglycosides. Med. Chem. Comm., 5, 1048-1057.
• Napan, K., Zhang, S., Morgan, W., Anderson, T., Takemoto, J.Y, Zhan, J., (2014). Synergistic actions of tailoring enzymes in pradimicin biosynthesis. ChemBioChem, 5:15, 2289–2296.
• Golo, P.S, Gardner, D., Grilley, M.M, Takemoto, J.Y, Krasnoff, S.B, Pires, M.S, Fernandes, E.K, Bittencourt, V.R, Roberts, D.W, (2014). Production of destruxins from Metarhizium spp. fungi in artificial medium and in endophytically colonized cowpea plants.. PloS one, 9:8, e104946.
• Ito, T., Chen, D., Chang, C.T, Kenmochi, T., Saito, T., Suzuki, S., Takemoto, J.Y, (2013). Mesobiliverdin IXalpha enhances rat pancreatic islet yield and function. Frontiers in Pharmacology, 4:50, doi: DOI10.3389/fphar.2013.00050
• Shrestha, S., Grilley, M.M, Fosso, M.Y, Chang, C.T, Takemoto, J.Y, (2013). Membrane lipid-modulated mechanism of action and non-cytotoxicity of novel fungicide aminoglycoside FG08. PloS one, 8:9, e73843.
• Chen, D., Kawasaki, Y., Brown, J., Takemoto, J.Y, (2012). Scalable bioproduction of biliverdin IXalpha by Escherichia coli. BMC Biotechnology, 12, 89. doi: DOI:10.1186/1472-6750-12-89
• Bessonov, A., Takemoto, J.Y, Simmel, F., (2012). Probing DNA - lipid membrane interactions with a lipopeptide nanopore.. ACS Nano, 6:4, 3356-3363.
• Napan, K.L, Zeng, J., Takemoto, J.Y, Zhan, J., (2012). A key cytochrome P450 hydroxylase in pradimicin biosynthesis. Bioorganic and Medicinal Chemistry Letters , 22:1, 606-609. doi: doi:10.1016/j.bmcl.2011.10.075
• Bensaci, M.F, Gurnev, P.A, Bezrukov, S.M, Takemoto, J.Y, (2011). Fungicidal activities and mechanisms of action of Pseudomonas syringae pv. syringae lipodepsipeptide syringopeptins 22A and 25A. Frontiers in Microbiology, 2:216, doi: 10.3389/fmicb.2011.00216
• Chang, C.W, Fosso, M., Kawasaki, Y., Shrestha, S., Bensaci, M.F, Wang, J., Evans, C.K, Takemoto, J.Y, (2010). Antibacterial to antifungal conversion of neamine aminoglycosides through alkyl modification. Strategy for reviving old drugs into agrofungicides. Journal of Antibiotics, 63:11, 667-672.
• Takemoto, J.Y, Bensaci, M., De Lucca, A.J, Cleveland, T.E, Gandhi, N.R, Skebba, V.P, (2010). Inhibition of fungi from diseased grape by syringomycin E-rhamnolipid mixture. Amer. J. Enol. Viti., 61:1, 120-124.
• Chang, C.T, Fosso, M., Kawasaki, Y., Bensaci, M., Evans, C.K, Wang, J.H, Shrestha, S., Takemoto, J.Y, (2010). Antibacterial to antifungal conversion of neamine aminoglycoisodes through alkyl modification. Strategy for reviving an old drug into agrofungicides. J. Antibiotics, 63, 667-672.
• Zhang, J.J, Keller, K., Takemoto, J.Y, Bensaci, M., Litke, A., Czyryca, P.G, Chang, C.W, (2009). Synthesis and combinational antibacterial study of 5 ”-modified neomycin. Journal of Antibiotics, 62:10, 539-544.
• Ostroumova, O.S, Malev, V.V, Bessonov, A.N, Takemoto, J.Y, Schagina, L.V, (2008). Altering the activity of syringomycin e via the membrane dipole potential. Langmuir, 24:7, 2987-2991.
• Fiore, A., Mannina, L., Sobolev, A.P, Salzano, A.M, Scaloni, A., Grgurina, I., Fullone, M.R, Gallo, M., Swasey, C., Fogliano, V., Takemoto, J.Y, (2008). Bioactive lipopeptides of ice-nucleating snow bacterium Pseudomonas syringae strain 31R1. Fems Microbiology Letters, 286:2, 158-165.
• Ostroumova, O., Schagina, L., Gurnev, P., Takemoto, J.Y, Bezrukov, S., (2007). Probing pore geometry of the syringomycin E channel with polyethylene glycols. Biophysical Journal, 613A-614A.
• Zhang, J.J, Chen, H., Chiang, F.I, Takemoto, J.Y, Bensaci, M., Chang, C.W, (2007). Sonication-assisted library synthesis of oxazolidinone-carbohydrate conjugates. Journal of Combinatorial Chemistry, 9:1, 17-19.
• Bensaci, M.F, Takemoto, J.Y, (2007). Syringopeptin SP25A-mediated killing of gram-positive bacteria and the role of teichoic acid D-alanylation. Fems Microbiology Letters, 268:1, 106-111.
• Takemoto, J.Y, (2007). Syringopeptin SP25A-mediated killing of Gram-positive bacteria and role of teichoic acid D-alanylation. FEMS Microbiol Lett, 268, 106-111.
• Bessonov, A.N, Schagina, L.V, Takemoto, J.Y, Gurnev, P.A, Kuznetsova, I.M, Turoverov, K.K, Malev, V.V, (2006). Actin and amphiphilic polymers influence on channel formation by Syringomycin E in lipid bilayers. European Biophysics Journal with Biophysics Letters, 35:5, 382-392.
• Bessonov, A.N, Schagina, L.V, Turoverov, K.K, Kumetsova, I., Takemoto, J.Y, Malev, V.V, (2006). Influence of cooperative adsorption of macromolecules on the channel-forming activity of syringomycin E in lipid bilayers. Biologicheskie Membrany, 23:3, 261-270.
• Bessonov, A.N, Schagina, L.V, Kuznetsova, I.M, Takemoto, J.Y, Turoverov, K.K, Malev, V.V, (2005). Cooperative adsorption of actin on syringomycin E modified planar lipid bilayers. FEBS Journal, 272, 234-234.
• Ostroumova, O.S, Gurnev, P.A, Takemoto, J.Y, Malev, V.V, Schagina, L.V, (2005). Kinetic parameters of cyclic lipodepsipeptide ion channels in planar lipid bilayers. Biophysical Journal, 88:1, 248A-248A.
• Grgurina, I., Bensaci, M., Pocsfalvi, G., Mannina, L., Cruciani, O., Fiore, A., Fogliano, V., Sorensen, K.N, Takemoto, J.Y, (2005). Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities. Antimicrobial Agents and Chemotherapy, 49:12, 5037-5045.
• Thevissen, K., Idkowiak-Baldys, J., Im, Y.J, Takemoto, J.Y, Francois, I. E. J. A., , Ferket, K.K, Takemoto, J.Y, Meert, E.M, Winderickx, J., Roosen, J., Cammue, B.P, (2005). SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. FEBS Letters, 579:9, 1973-1977.
• Thevissen, K., Idkowiak-Baldys, J., Im, Y.J, Takemoto, J.Y, Francois, I. E. J. A., , Ferket, K.K, Takemoto, J.Y, Meert, E.M, Winderickx, J., Roosen, J., Cammue, B.P, (2005). SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. FEBS Letters, 579:9, 1973-1977.
• Kaulin, Y.A, Takemoto, J.Y, Schagina, L.V, Ostroumova, O.S, Wangspa, R., Teeter, J.H, Brand, J.G, (2005). Sphingolipids influence the sensitivity of lipid bilayers to fungicide, syringomycin E. Journal of Bioenergetics and Biomembranes, 37:5, 339-348.
• Bessonov, A.N, Babakov, V.N, Kuznetsova, I.M, Turoverov, K.K, Malev, V.V, Takemoto, J.Y, Schagina, L.V, (2005). Structural specificity of G-actin adsorption on model lipid membranes. Biophysical Journal, 88:1, 425A-425A.
• Schagina, L.V, Ostroumova, O.S, Gurnev, P.A, Takemoto, J.Y, Malev, V.V, (2005). Voltage-dependent synchronization of gating of cyclic lipodepsipeptide ion channels in planar lipid bilayers. Biophysical Journal, 88:1, 247A-247A.
• Bensaci, M., Grgurina, I., Pocsfavi, G., Mannina, L., Cruciani , O., Fiore, A., Fogliani, V., Sorensen, K.N, Takemoto, J.Y, (2005). Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities. Antimicrob. Agents Chemother., 49, 5037-5045.
• Elchert, B., Li, J.K, Wang, J., Hui, Y., Rai, R., Ptak, R., Ward, P., Takemoto, J.Y, Bensaci, M., Chang, C.W, (2004). Application of the synthetic aminosugars for glycodiversification: Synthesis and antimicrobial studies of pyranmycin. Journal of Organic Chemistry, 69:5, 1513-1523.
• Gurnev, P.A, Bessonov, A.N, Takemoto, J.Y, Shchagina, L.V, Malev, V.V, (2004). Conductance of ion channels induced by syringomycin E in lipid bilayers with asymmetrically distributed surface charge. Biologicheskie Membrany, 21:4, 325-332.
• Bessonov, A.N, Gurnev, P.A, Malev, V.V, Takemoto, J.Y, Schagina, L.V, (2004). Koning’s polyanion modulates syringomycin E-induced conductance of lipid bilayers. Biophysical Journal, 86:1, 206A-206A.
• Idkowiak-Baldys, J., Grilley, M.M, Takemoto, J.Y, (2004). Sphingolipid C4 hydroxylation influences properties of yeast detergent-insoluble glycolipid-enriched membranes. FEBS Letters, 569:1-3, 272-276.
• Wang, J., Elchert, B., Hui, Y., Takemoto, J.Y, Bensaci, M., Wennergren, J., Chang, H., Rai, R., Chang, C.W, (2004). Synthesis of trehalose-based compounds and their inhibitory activities against Mycobacterium smegmatis. Bioorganic & Medicinal Chemistry, 12:24, 6397-6413.
• I.Y, M, G.M, Takemoto, J.Y, (2004). Sphingolipid C4 hydroxylation influences properties of yeast detergent-insoluble glycolipid-enriched membranes. FEBS Lett, 569, 272-276.
• Thevissen, K., Francois, I. E. J. A., , Takemoto, J.Y, Ferket, K.K, Meert, E.M, Cammue, B.P, (2003). DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae. Fems Microbiology Letters, 226:1, 169-173.
• Schagina, L.V, Gurnev, P.A, Takemoto, J.Y, Malev, V.V, (2003). Effective gating charge of ion channels induced by toxin syringomycin E in lipid bilayers. Bioelectrochemistry, 60:1-2, 21-27.
• Gurnev, P.A, Bessonov, A.N, Kuznetsova, I.M, Malev, V.V, Pershina, V.P, Pinaev, G.P, Takemoto, J.Y, Tikhomirova, A.V, Turoverov, K.K, Schagina, L.V, (2003). Effects of actin and polyions on channel-forming activity of syringomycin E in bilayer lipid membranes. Biologicheskie Membrany, 20:5, 425-432.
• Im, Y.J, Idkowiak-Baldys, J., Thevissen, K., Cammue, B.P, Takemoto, J.Y, (2003). IPT1-independent sphingolipid syringomycin E and biosynthesis and yeast inhibition by plant defensin DmAMP1. Fems Microbiology Letters, 223:2, 199-203.
• Chang, C.W, Elchert, B., Hui, Y., Wang, J., Wennergren, J., Rai, R., Takemoto, J.Y, Bensaci, M., (2003). Novel trehalose-based compounds against Mycobacterium, synthesis and antibacterial studies.. Abstracts of Papers of the American Chemical Society, 226, U212-U212.
• Idkowiak-Baldys, J., Takemoto, J.Y, Grilley, M.M, (2003). Structure– function studies of yeast C-4 sphingolipid long chain base hydroxylase. Biochimica et Biophysica Acta (BBA)/Biomembranes, 1618, 17-24.
• Gurnev, P.A, Kaulin, Y.A, Takemoto, J.Y, Schagina, L.V, Malev, V.V, (2002). Effects of charges and dipole moments of membrane lipids on gating properties of ion channels induced by syringomycin E. Biologicheskie Membrany, 19:3, 243-249.
• Malev, V.V, Schagina, L.V, Gurnev, P.A, Takemoto, J.Y, Nestorovich, E.M, Bezrukov, S.M, (2002). Syringomycin E channel: A lipidic pore stabilized by lipopeptide?. Biophysical Journal, 82:4, 1985-1994.
• Szabo, Z., Grof, P., Schagina, L.V, Gurnev, P.A, Takemoto, J.Y, Matyus, E., Blasko, K., (2002). Syringotoxin pore formation and inactivation in human red blood cell and model bilayer lipid membranes. Biochimica et Biophysica Acta, 1567:1-2, 143-149.
• Wang, J., Li, J.K, Tuttle, D., Takemoto, J.Y, Chang, C.W, (2002). The synthesis of L-aminosugar and the studies of L-pyranoses on the ring III of pyranmycins. Organic Letters, 4:23, 3997-4000.
• Malev, V.V, Kaulin, Y.A, Bezrukov, S.M, Gurnev, P.A, Takemoto, J.Y, Schagina, L.V, (2001). Kinetics of opening-closure of syringomycin E channels formed in lipid bilayers. Membrane Cell Biology, 14, 813-829.
• Malev, V.V, Kaulin, Y.A, Gurnev, P.A, Bezrukov, S.M, Takemoto, J.Y, Shchagina, L.V, (2001). Spatial charge distribution effects in the conductance of syringomycin E ion channels formed in lipid bilayers.. Biologicheskie Membrany, 18:2, 145-153.
• Hama, H., Takemoto, J.Y, DeWald, D.B, (2000). Analysis of phosphoinositides in protein trafficking. Methods-a Companion to Methods in Enzymology, 20:4, 465-473.
• Kaulin, Y.A, Gurnev, P.A, Szabo, Z., Schagina, L.V, Takemoto, J.Y, Blasko, K., (2000). Membrane-permeabilizing activities of cyclic lipodepsipeptides, syringopeptin 22A and syringomycin E from Pseudomonas syringae pv. syringae in human red blood cells and in bilayer lipid membranes. Bioelectrochemistry, 52:2, 161-167.
• Stock, S.D, Hama, H., Radding, J.A, Young, D.A, Takemoto, J.Y, (2000). Syringomycin E inhibition of Saccharomyces cerevisiae: Requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Antimicrobial Agents and Chemotherapy, 44:5, 1174-1180.
• Agner, G., Kaulin, Y.A, Schagina, L.V, Blasko, K., Takemoto, J.Y, (2000). Effect of temperature on the formation and inactivation of syringomycin pores in red blood cells and bimolecular lipid membranes. Biochim. Biophys. Acta, 1466, 79-86.
• Grilley, M.M, Takemoto, J.Y, (2000). Assay of the Saccharomyces cerevisiae dihydrosphingosine C-4 hydroxylase.. Methods in enzymology, 311, 9-14.
• Hama, H., Schnieders, E.A, Thorner, J., Takemoto, J.Y, DeWald, D.B, (1999). Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. Journal of Biological Chemistry, 274:48, 34294-34300.
• De Lucca, A.J, Jacks, T.J, Takemoto, J.Y, Vinyard, B., Peter, J., Navarro, E., Walsh, T.J, (1999). Fungal lethality, binding, and cytotoxicity of syringomycin-E. Antimicrobial Agents and Chemotherapy, 43:2, 371-373.
• Stock, S.D, Hama, H., DeWald, D.B, Takemoto, J.Y, (1999). SEC14-dependent secretion in Saccharomyces cerevisiae - Nondependence on sphingolipid synthesis-coupled diacylglycerol production. Journal of Biological Chemistry, 274:19, 12979-12983.
• Kaulin, Y.A, Schagina, L.V, Bezrukov, S.M, Malev, V.V, Feigin, A.M, Takemoto, J.Y, Teeter, J.H, Brand, J.G, (1998). Cluster organization of ion channels formed by the antibiotic syringomycin E in bilayer lipid membranes. Biophysical Journal, 74:6, 2918-2925.
• Sorensen, K.N, Wanstrom, A.A, Allen, S., Takemoto, J.Y, (1998). Efficacy of syringomycin E in a murine model of vaginal candidiasis. Journal of Antibiotics, 51:8, 743-749.
• Blasko, K., Schagina, L.V, Takemoto, J.Y, Kaulin, Y.A, (1998). Membrane sterol composition modulates the pore forming activity of syringomycin E in human red blood cells. Biochimica Et Biophysica Acta-Biomembranes, 1373:1, 163-169.
• Sorensen, K.N, Kim, K.H, Takemoto, J.Y, (1998). PCR detection of cyclic lipodepsinonapeptide-producing Pseudomonas syringae pv syringae and similarity of strains. Applied and Environmental Microbiology, 64:1, 226-230.
• Schagina, L.V, Kaulin, Y.A, Feigin, A.M, Takemoto, J.Y, Brand, J.G, Malev, V.V, (1998). Properties of ion channels formed by the antibiotic syringomycin E in lipid bilayers: Dependence on the electrolyte concentration in the bathing solution. Biologicheskie Membrany, 15:4, 433-446.
• Bull, C.T, Wadsworth, M.L, Sorensen, K.N, Takemoto, J.Y, Austin, R.K, Smilanick, J.L, (1998). Syringomycin E produced by biological control agents controls green mold on lemons. Biological Control, 12:2, 89-95.
• Grilley, M.M, Stock, S.D, Dickson, R.C, Lester, R.L, Takemoto, J.Y, (1998). Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae.. The Journal of biological chemistry, 273:18, 11062-8.
• Feigin, A.M, Schagina, L.V, Takemoto, J.Y, Teeter, J.H, Brand, J.G, (1997). The effect of sterols on the sensitivity of membranes to the channel-forming antifungal antibiotic, syringomycin E. Biochimica Et Biophysica Acta-Biomembranes, 1324:1, 102-110.
• Sorensen, K.N, Kim, K.H, Takemoto, J.Y, (1996). In vitro antifungal and fungicidal activities and erythrocyte toxicities of cyclic lipodepsinonapeptides produced by Pseudomonas syringae pv syringae. Antimicrobial Agents and Chemotherapy, 40:12, 2710-2713.
• Grgurina, I., Gross, D.C, Iacobellis, N.S, Lavermicocca, P., Takemoto, J.Y, Benincasa, M., (1996). Phytotoxin production by Pseudomonas syringae pv syringae: Syringopeptin production by syr mutants defective in biosynthesis or secretion of syringomycin. Fems Microbiology Letters, 138:1, 35-39.
• Feigin, A.M, Takemoto, J.Y, Wangspa, R., Teeter, J.H, Brand, J.G, (1996). Properties of voltage-gated ion channels formed by syringomycin E in planar lipid bilayers. Journal of Membrane Biology, 149:1, 41-47.
• Singh, V.K, Takemoto, J.Y, (1996). Suppression of mitogen-induced lymphocyte proliferation by syringomycin-E. Fems Immunology and Medical Microbiology, 15:2-3, 177-179.
• Cliften, P., Wang, Y.L, Mochizuki, D., Miyakawa, T., Wangspa, R., Hughes, J., Takemoto, J.Y, (1996). SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae. Microbiology-Uk, 142, 477-484.
• DiGiorgio, D., Camoni, L., Mott, K.A, Takemoto, J.Y, Ballio, A., (1996). Syringopeptins, Pseudomonas syringae pv syringae phytotoxins, resemble syringomycin in closing stomata. Plant Pathology, 45:3, 564-571.
• Takemoto, J.Y, Ballio, A., Isogai, A., (1995). Other Lipopeptides. Science, 267:5198, 605-605.
• Takemoto, J.Y, Isogai, A., Digiorgio, D., Ballio, A., (1995). Saprophytic Pseudomonas-Syringae Strain M1 of Wheat Produces Cyclic Lipodepsipeptides. Fems Microbiology Letters, 131:1, 63-67.
• Isogai, A., Iguchi, H., Nakayama, J., Kusai, A., Takemoto, J.Y, Suzuki, A., (1995). Structural-Analysis of New Syringopeptins by Tandem Mass-Spectrometry. Bioscience Biotechnology and Biochemistry, 59:7, 1374-1376.
• Hemmi, K., Julmanop, C., Hirata, D., Tsuchiya, E., Takemoto, J.Y, Miyakawa, T., (1995). The Physiological Roles of Membrane Ergosterol as Revealed by the Phenotypes of Syr1/Erg3 Null Mutant of Saccharomyces-Cerevisiae. Bioscience Biotechnology and Biochemistry, 59:3, 482-486.
• Taguchi, N., Takano, Y., Julmanop, C., Wang, Y.L, Stock, S., Takemoto, J.Y, Miyakawa, T., (1994). Identification and Analysis of the Saccharomyces-Cerevisiae Syr1 Gene Reveals That Ergosterol Is Involved in the Action of Syringomycin. Microbiology-Uk, 140, 353-359.
• Julmanop, C., Takano, Y., Takemoto, J.Y, Miyakawa, T., (1993). Protection by Sterols against the Cytotoxicity of Syringomycin in the Yeast Saccharomyces-Cerevisiae. Journal of General Microbiology, 139, 2323-2327.
• Takemoto, J.Y, Yu, Y.X, Stock, S.D, Miyakawa, T., (1993). Yeast Genes Involved in Growth-Inhibition by Pseudomonas-Syringae Pv Syringae Syringomycin Family Lipodepsipeptides. Fems Microbiology Letters, 114:3, 339-342.
• Tai, Y.S, Takemoto, J.Y, (1992). Removing coomassie blue from polyacrylamide gels. Biotechniques, 12:3, 388-388.
• Fukuchi, N., Isogai, A., Nakayama, J., Takayama, S., Yamashita, S., Suyama, K., Takemoto, J.Y, Suzuki, A., (1992). Structure and stereochemistry of three phytotoxins, syringomycin, syringotoxin and syringostatin, produced by Pseudomonas syringae pv syringae. Journal of the Chemical Society-Perkin Transactions 19, 1149-1157.
• Suzuki, Y.S, Wang, Y.L, Takemoto, J.Y, (1992). Syringomycin-stimulated phosphorylation of the plasma-membrane H+-ATPase from red beet storage tissue. Plant Physiology, 99:4, 1314-1320.
• Kauss, H., Waldmann, T., Jeblick, W., Takemoto, J.Y, (1991). The phytotoxin syringomycin elicits Ca2+-dependent callose synthesis in suspension-cultured cells of Catharanthus roseus. Physiologia Plantarum, 81:1, 134-138.
• Takemoto, J.Y, Zhang, L., Taguchi, N., Tachikawa, T., Miyakawa, T., (1991). Mechanism of action of the phytotoxin syringomycin. A resistant mutant of Saccharomyces cerevisiae reveals an involvement of Ca2+ transport. J. Gen. Microbiol. , 136, 653-659.
• Fukuchi, N., Isogai, A., Yamashita, S., Suyama, K., Takemoto, J.Y, Suzuki, A., (1990). Structure of Phytotoxin Syringomycin Produced by a Sugar-Cane Isolate of Pseudomonas-Syringae Pv Syringae. Tetrahedron Letters, 31:11, 1589-1592.
• Reidl, H.H, Grover, T.A, Takemoto, J.Y, (1989). P-31-Nmr Evidence for Cytoplasmic Acidification and Phosphate Extrusion in Syringomycin-Treated Cells of Rhodotorula-Pilimanae. Biochimica Et Biophysica Acta, 1010:3, 325-329.
• Mott, K.A, Takemoto, J.Y, (1989). Syringomycin, a Bacterial Phytotoxin, Closes Stomata. Plant Physiology, 90:4, 1435-1439.
• Reidl, H.H, Grover, T.A, Takemoto, J.Y, (1989). 31-P-NMR evidence for cytoplasmic acidification and phosphate extrusion in syringomycin-treated cells of Rhodotorula pilimanae. Biochem. Biophy. Acta, 1010, 325-329.
• Zhang, L., Takemoto, J.Y, (1989). Syringomycin stimulation of potassium efflux by yeast cells. Biochim. Biophys. Acta , 987, 171-173.
• Takemoto, J.Y, (1989). The Structure of Syringomycins A, E and G. FEBS Letter 255:27-31
• Tadros, M.H, Frank, R., Takemoto, J., Drews, G., (1988). Localization of Reaction Center and B800-850 Antenna Pigment Proteins in Membranes of Rhodobacter-Sphaeroides. Journal of Bacteriology, 170:6, 2758-2762.
• Reinbold, R., Takemoto, J.Y, (1988). Use of Swiss Cheese Whey Permeate by Kluyveromyces fragilis and Mixed Culture of Rhodopseudomonas sphaeroides and Bacillus megaterium. Journal of Dairy Science, 71:7, 1799-1802.
• Tadros, M.H, Frank, R., Doerge, B., Gad'on, N., Takemoto, J.Y, Drews, G., (1987). Orientation of the B800-850, B870, and reaction center polypeptides on the cytoplasmic and periplasmic surfaces of Rhodobacter capsulata membranes. Biochemistry, 26:24, 7680-7687.
• Bidwai, A.P, Takemoto, J.Y, (1987). Bacterial Phytotoxin, Syringomycin, Induces a Protein Kinase-Mediated Phosphorylation of Red Beet Plasma-Membrane Polypeptides. Proceedings of the National Academy of Sciences of the United States of America, 84:19, 6755-6759.
• Bidwai, A.P, Takemoto, J.Y, (1987). Bacterial Phytotoxin, Syringomycin, Stimulates a Protein-Kinase Mediated Phosphorylation of Red Beet Plasma-Membrane Polypeptides. Journal of Cellular Biochemistry, 93-93.
• Lei, Z., Takemoto, J.Y, (1987). Effects of Pseudomonas-Syringae Phytotoxin, Syringomycin, on Plasma-Membrane Functions of Rhodotorula-Pilimanae. Phytopathology, 77:2, 297-303.
• Tadros, M.H, Frank, R., Dorge, B., Gadon, N., Takemoto, J.Y, Drews, G., (1987). Orientation of the B800-850, B870, and Reaction Center Polypeptides on the Cytoplasmic and Periplasmic Surfaces of Rhodobacter-Capsulatus Membranes. Biochemistry, 26:24, 7680-7687.
• Takemoto, J.Y, Peterson, R.L, Tadros, M.H, Drews, G., (1987). Transverse Membrane Topography of the B875 Light-Harvesting Polypeptides of Wild-Type Rhodobacter-Sphaeroides. Journal of Bacteriology, 169:10, 4731-4736.
• Bidwai, A.P, Takemoto, J.Y, (1987). Bacterial phytotoxin, syringomycin, induces a protein kinase-mediated phosphorylation of red beet plasma membrane polypeptides. Proceedings of the National Academy of Sciences, 84:19, 6755-6759.
• Reidl, H., Takemoto, J.Y, (1987). Mechanism of action of bacterial phytotoxin, syringomycin. Simultaneous measurement of early responses in yeast and maize. Biochimica et Biophysica Acta (BBA) - Biomembranes, 898:1, 59-69.
• Zhang, L., Takemoto, J.Y, (1986). Mechanism of action of Pseudomonas syringae phytotoxin, syringomycin. Interaction with the plasma membrane of wild-type and respiratory-deficient strains of Saccharomyces cerevisiae. Biochimica et Biophysica Acta (BBA) - Biomembranes, 861, 201-204.
• Takemoto, J.Y, Schonhardt, T., Golecki, J.R, Drews, G., (1985). Fusion of Liposomes and Chromatophores of Rhodopseudomonas-Capsulata - Effect on Photosynthetic Energy-Transfer between B875 and Reaction Center Complexes. Journal of Bacteriology, 162:3, 1126-1134.
• Wilson, E., Farley, T.M, Takemoto, J.Y, (1985). Photoaffinity-labeling of an antimycin-binding site in Rhodopseudomonas sphaeroides. Journal of Biological Chemistry, 260:18, 288-292.
• Zhang, L., Takemoto, J.Y, (1985). Pseudomonad phytotoxin, syringomycin stimulates the plasma-membrane ATPase of Rhodotorula pilimanae. Phytopathology, 75:11, 1381-1381.
• Bachmann, R.C, Takemoto, J.Y, (1983). Near-Neighbor Relationships of the Photosynthetic Reaction Center Polypeptides of Rhodopseudomonas-Sphaeroides. Biochemistry International, 7:2, 137-145.
• Bachmann, R.C, Tadros, M.H, Oelze, J., Takemoto, J.Y, (1983). Purification and Characterization of the B875 Light-Harvesting Complex of Rhodopseudomonas-Sphaeroides. Biochemistry International, 7:5, 629-634.
• Peters, J., Takemoto, J.Y, Drews, G., (1983). Spatial relationships between the photochemical-reaction Center and the Light-Harvesting Complexes in the Membrane of Rhodopseudomonas-Capsulata. Biochemistry, 22:24, 5660-5667.
• Takemoto, J.Y, Peters, J., Drews, G., (1982). Crosslinking of photosynthetic membrane polypeptides of Rhodopseudomonas capsulata. FEBS Letters, 142:2, 227-230.
• Chen, J., Miller, G.W, Takemoto, J.Y, (1981). Biosynthesis of delta-aminolevulinic-acid in Rhodopseudomonas-Sphaeroides. Archives of Biochemistry and Biophysics, 208:1, 221-228.
• Bachmann, R.C, Gillies, K., Takemoto, J.Y, (1981). Membrane topography of the photosynthetic reaction center polypeptides of Rhodopseudomonas sphaeroides. Biochemistry, 20:16, 4590-4596.
• Al-Bayatti, K., Takemoto, J.Y, (1981). Phospholipid topography of the photosynthetic membrane of Rhodopseudomonas sphaeroides. Biochemistry, 20:19, 5489-5495.
• Kendall-Tobias, M., Takemoto, J.Y, (1981). Simple, compact, and inexpensive light-dark attachment for scanning spectrophotometers. Rev Sci Instru, 52:1, 141-142.
• Gillies, K., Takemoto, J.Y, (1981). Absence of reaction center subunit H in bacteriochlorophyll mutant 8-17 ofRhodopseudomonas sphaeroides. FEMS Microbiology Letters, 12:1, 7-10.
• Takemoto, J.Y, Bachmann, R.C, (1979). Orientation of chromatophores and spheroplast-derived membrane vesicles of Rhodopseudomonas sphaeroides: Analysis by localization of enzyme activities. Archives of Biochemistry and Biophysics, 195:2, 526-534.
• Lommen, M.A, Takemoto, J.Y, (1978). Comparison, by Freeze-Fracture Electron-Microscopy, of Chromatophores, Spheroplast-Derived Membrane-Vesicles, and Whole Cells of Rhodopseudomonas-Sphaeroides. Journal of Bacteriology, 136:2, 730-741.
• Lommen, M.A, Takemoto, J.Y, (1978). Ultrastructure of Carotenoid Mutant Strain R-26 of Rhodopseudomonas-Sphaeroides. Archives of Microbiology, 118:3, 305-308.
• Takemoto, J.Y, Huang Kao, M.Y, (1977). Effects of Incident Light Levels on Photosynthetic Membrane Polypeptide Composition and Assembly in Rhodopseudomonas-Sphaeroides. Journal of Bacteriology, 129:2, 1102-1109.
• Takemoto, J.Y, Bogorad, L., (1975). Subunits of phycoerythrin from Fremyella diplosiphon - chemical and Immunochemical Characterization. Biochemistry, 14:6, 1211-1216.
• Takemoto, J.Y, Lascelles, J., (1974). Function of membrane proteins coupled to bacteriochlorophyll synthesis. Archives of Biochemistry and Biophysics, 163:2, 507-514.
• Takemoto, J.Y, (1974). Kinetics of photosynthetic membrane protein assembly in Rhodopseudomonas spheroides. Archives of Biochemistry and Biophysics, 163:2, 515-520.
• Takemoto, J.Y, Lascelles, J., (1973). Coupling between bacteriochlorophyll and membrane protein synthesis in Rhodopseudomonas spheroides. Proc Natl Acad Sci U S A, 70:3, 799-803.
• Andreoli, A.J, Suehiro, S., Sakiyama, D., Takemoto, J.Y, Vivanco, E., Lara, J.C, Klute, M.C, (1973). Release and recovery of forespores from Bacillus cereus. J Bacteriol, 115:3, 1159-66.

Public or Trade Journal

• Takemoto, J.Y, Chang, C.T, Shrestha, S.K, Grilley, M.M, (2017). Aminoglycoside and azole compositions and methods, US Patent 9,669,044 B2, Issued June 6 2017. U.S. Patent and Trademark Office
• Takemoto, J.Y, Chen, D., (2017). Recombinant non-animal cell for making biliverdin, US14/854,791, Issued Jan 20 2017. U.S. Patent and Trademark Office
• Takemoto, J.Y, Chen, D., Chang, C.T, (2015). Meso-biliverdin compositions and methods, US Patent 9242932 B2, Issued Jan 26 2016. United States Patent Office
• Takemoto, J.Y, Chen, D., Chang, C.T, Wood, J.L, (2015). Therapeutic meso-biliverdin IXalpha compositions and associated methods, US Patent 9119842 B2, Issued Sept 1 2015. US Patent and Trademark Office
• Takemoto, J.Y, Chen, D., Chang, C.T, Wood, J., (2014). Therapeutic compositions and associated methods, US20140079723 A1, WO2014043645A1 Issued March 20, 2014. US Patent and Trademark Office
• Takemoto, J.Y, Chen, D., (2013). Biliverdin from Non-Animal Source, U.S. Patent 8,455,222,B2. U.S. Patent and Trademark Office
• Chang, C.T, Takemoto, J.Y, (2009). New Aminoglycosides: synthesis and use as antifungals PCT/US2009/046827 . US Patent and Trademark Office
• Takemoto, J.Y, (2007). Method for making fungi compatible artificial snow. U.S. Patent application ser no 20060248793, Nov. 9, 2006
• Takemoto, J.Y, Forney, J., Healey, M., Yang, S., Werbovetz, K., (2001). Method of controlling protozoan infections using syringomycin-family lipodepsipeptides. US Patent and Trademark Office, US6,310,037
• Takemoto, J.Y, (1998). Lipodepsipeptides as antifungal and fungicidal agents. U.S. Patent and Trademark Office

* Has not been peer reviewed

Publications - Literary Journal

* Has not been peer reviewed

Publications - MultiMedia

* Has not been peer reviewed

Publications - Technical Reports

* Has not been peer reviewed

Publications - Translations & Transcripts

Publications - Other

Other

• Takemoto, J.Y, (2009). New synthetic antifungal agents. USU Technology Notification/Invention Disclosure *
• Takemoto, J.Y, (2009). Novel antimicrobial aminoglycosides: synthesis and use as antifungals. PCT Utility Patent Application 61258126 *
• Takemoto, J.Y, (2006). Bacterial inhibition by natural products produced by pseudomonads. *

* Has not been peer reviewed

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