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Jon Takemoto

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Biology

Professor - Biology Department

Professor

Contact Information

Office Location: BNR 353
DialPhone: 435-797-0671
SendEmail: jon.takemoto@usu.edu


Educational Background

PhD, University of California, Los Angeles, 1973

Teaching Interests

microbiology

Research Interests

Microbiology, biochemistry, and synthetic biology to address current issues in agriculture, medicine and the environment. The focus is on microbial natural products and derivatives with novel antimicrobial and cytoprotective capabilities.

Awards

Teacher Who Made a Difference, 2009

University of Kentucky, College of Education

Graduate Mentor of the Year, 2002

Utah State University

Faculty Honor Lecturer, 1993

Utah State University

Researcher of the Year, 1990

College of Science

Long-Term Research Fellowship, 1988

Japan Society for the Promotion of Science

Alexander von Humboldt Foundation Fellowship, 1981

Federal Republic of Germany

NIH Postdoctoral Fellowship, 1974

Harvard University

Maria Moors Cabot Fellowship, 1973

Harvard University

UCLA Alumni Award, Academic Distinction in Graduate Studies, 1973

UCLA

NIH Predoctoral Fellowship, 1970

UCLA

Publications - Abstracts

  • Takemoto, J.Y, (2007). Probing the pore geometry of the syringomycin E channel with polyethylene glycols. Biophys. J. *
  • Takemoto, J.Y, (2005). Saccharomyces cerevisiae mutants with altered levels of the sphingolipid class of M(IP)2Cs display differential sensitivities to the antifungal plant defensin DmAMP1. Yeast *
  • Takemoto, J.Y, (1997). Efficacy of syringomycin E, a new antifungal, in a murine model of vaginal candidiasis. Annual Mtg., Intermountain Branch of the American Society for Microbiology, Abstracts, Vol. 45 *
  • Takemoto, J.Y, (1997). Sterol-dependent pore formation of syringomycin E on red blood cell membranes. Eur. Biophys. J. 26:66 *
  • Takemoto, J.Y, (1997). Syringomycin E, a new antifungal, in a murine model of vaginal candidiasis: efficacy and local toxicity. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A-041, Miami Beach, FL *
  • Takemoto, J.Y, (1997). Cloning and characterization of SYR4, a novel Saccharomyces cerevisiae gene involved in the response to syringomycin. Intrmtn. Branch, Amer. Soc. for Microbiology, Annual Mtg., Abstracts, Vol. 45, Dugway, Utah. April 26 *
  • Takemoto, J.Y, (1997). Yeast Cell Binding Studies With Radiolabled Syringomycin. Annual Mtg., Intermountain Branch, American Society for Microbiology, Abstracts, Vol. 45. Dugway, Utah, April 26 *
  • Takemoto, J.Y, (1996). CLP-3A, a Novel Antifungal Agent from Pseudomonas Syringae. Abstracts, Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A11 (abstract) *
  • Takemoto, J.Y, (1996). Isolation and characterization of novel syringomycin resistant mutants of Saccharomyces cerevisiae. Abstracts, Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A13 *
  • Takemoto, J.Y, (1996). Production, purification and in vitro antifimgal activity of syringostatin -A, a new antifungal agent produced by Pseudomonas syringae pv. syringae. Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A12 (abstract) *
  • Takemoto, J.Y, (1996). Role of secondary metabolites in biological control by Pseudomonas syringae pv. syringae strains ESC-10 and ESC-11. Abstracts, 8th International Congress of Molecular Plant-Microbe Interactions, Knoxville, TN, July 14-20 (abstract) *
  • Takemoto, J.Y, (1996). The influence of sterol and phospholipid structure on the properties of syringomycin E-induced channels. Biophys. J. 70(2):Al94 (Abstract) *
  • Takemoto, J.Y, (1996). Voltage-gated ion channels formed by syringomycin E in planar lipid bilayers. Biophys. J. 70(2):A194 (Abstract) *
  • Takemoto, J.Y, (1995). A novel bioactive lipodepsipeptide produced by Pseudomonas syringae cherry isolate. Abstracts, Ann. Mtg., Intermountain Branch, Amer. Soc. Microbiol. 43:B8 *
  • Takemoto, J.Y, (1995). Function of syringomycin response gene, SYR2, in yeast sterol metabolism. Abstracts, 95th Ann. Meet. Amer. Soc. Microbiol. A95 *
  • Takemoto, J.Y, (1995). In vitro activity of syringomycin E, a new antifungal produced by Pseudomonas syringae pv. syringae. Abstracts, Ann. Mtg., Intrmntn. Branch Amer. Soc. Microbiol. 43:B10 *
  • Takemoto, J.Y, (1995). In vitro antifungal and fungicidal activity of a cyclic lipodepsipeptide, syringomycin E. Abstracts, 35th Interscience Conf. Antimicrob. Agents and Chemotherapy, F103 *
  • Takemoto, J.Y, (1995). Role of H2O2 in Syringomycin Action Against Yeast. Abstracts, Ann. Mtg., Intrmntn. Branch, Amer. Soc. Microbiol. 43:B9 *
  • Takemoto, J.Y, (1994). Influence of cellular sterol composition on syringomycin inhibition of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A95 *
  • Takemoto, J.Y, (1994). Isolation and characterization of novel syringomycin-resistant mutants of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A94 *
  • Takemoto, J.Y, (1994). SYR2: A Novel Yeast Gene Involved in the Response to Syringomycin. Abs. Ann. Meet. Amer. Soc. Microbiol. A93 *
  • Takemoto, J.Y, (1993). Antifungal properties of Pseudomonas syringae pv. syringae strain M1 from wheat seed coat. Abstracts, Ann. Mtg., Inter. Branch, Amer. Soc. Microbiol. 41:A4 *
  • Takemoto, J.Y, (1993). Cloning and characterization of SYR2: A novel gene of Saccharomyces cerevisiae involved in the response to syringomycin. Abstracts, Ann. Mtg., Interm. Branch, Amer. Soc. Microbiol. 41:A.5 *
  • Takemoto, J.Y, (1993). Identification of gene, SYR1, involved in syringomycin inhibition of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Interm. Branch, Amer. Soc. Microbiol. 41:A3 *
  • Takemoto, J.Y, (1993). Properties of Syringomycin-Resistant Mutants of Saccharomyces Cerevisiae. Abstracts *
  • Takemoto, J.Y, (1992). Saccharomyces cerevisiae genes involved in the response to Pseudomonas syringae phytotoxin, syringomycin. Phytopathology 82:1126 *
  • Takemoto, J.Y, (1991). Syringomycin-stimulated phosphorylation of the red beet plasma membrane H+-ATPase. Plant Physiol. 96:446 *

Publications - Books & Book Chapters

    Book Chapters

  • Takemoto, J.Y, (2008). Voltage-dependent ion channels induced by cyclic lipodepsipeptides in planar lipid bilayers: structure, properties, and resemblance to native channels. Advances in Planar Lipid Bilayers and Liposomes, 8.
  • Takemoto, J.Y, (2003). The syringomycins: lipodepsipeptide pore formers from plant bacterium, Pseudomonas syringae. Pore Forming Peptides and Protein Toxins
  • Takemoto, J.Y, (2000). Analysis of Phosphoinositides in Protein Trafficking. In, Methods: A Companion to Methods in Enzymology
  • Takemoto, J.Y, (2000). Assay of the Saccharomyces Cerevisiae Dihydrosphingosine C-4 Hydroxylase. Methods in Enzymol. *
  • Takemoto, J.Y, (1992). Bacterial Phytotoxin Syringomycin and Its Action on Host Membranes. IN: Molecular Signals in Plant-Microbe Communications, (ed). D.P.S. Verma. P. 247-260
  • Takemoto, J.Y, (1989). Structure of Syringomycin. A Progress Report. p. 359-361. IN: A. Graniti, R.D. Durbin and A. Ballio (eds.), Phytotoxins and Plant Pathogenesis. Springer-Verlag, Berlin-Heidelberg
  • Takemoto, J.Y, (1989). Syringomycin Effects on Plasma Membrane Ca+2 Transport, p. 167-175. IN: A. Graniti, R. D. Durbin & A. Ballio (eds.), Phytotoxins & Plant Pathogenesis

* Has not been peer reviewed

Publications - Fact Sheets

    * Has not been peer reviewed

    Publications - Curriculum

      * Has not been peer reviewed

      Publications - Journal Articles

      * Has not been peer reviewed

      Publications - Literary Journal

        * Has not been peer reviewed

        Publications - MultiMedia

          * Has not been peer reviewed

          Publications - Technical Reports

            * Has not been peer reviewed

            Publications - Translations & Transcripts

              Publications - Other

                Other

              • Takemoto, J.Y, Chen, D., Chang, C.T, Jonathan, W.L, (2015). Therapeutic mesobiliverdin IXalpha compositions and associated methods, Patent assigned, US9119842 B2. United States Patent Office
              • Takemoto, J.Y, Chang, C.W, Shrestha, S.K, Grilley, M.M, (2014). Aminoglycoside and Azole Compositions and Methods. Google Patents
              • Takemoto, J.Y, Chen, D., Chang, C.T, Jonathan, W.L, (2014). Therapeutic compositions and associated methods. World Intellectual Property Organization
              • Takemoto, J.Y, Chen, D., (2013). Biliverdin from Non-Animal Source, U.S. Patent 8,455,222,B2. U.S. Patent and Trademark Office
              • Takemoto, J.Y, (2009). New synthetic antifungal agents. USU Technology Notification/Invention Disclosure *
              • Takemoto, J.Y, (2009). Enhanced bioproduction of biliverdin-IX alpha. Provisional Patent Application 61258126 *
              • Takemoto, J.Y, (2009). Novel antimicrobial aminoglycosides: synthesis and use as antifungals. PCT Utility Patent Application 61258126 *
              • Takemoto, J.Y, (2007). Antimycotic rhamnolipid compositions and related methods of use. U.S.Patent, application serial no. 11/351,572, Feb. 2, 2006 *
              • Takemoto, J.Y, (2007). Method for making fungi compatible artificial snow. U.S. Patent application serial no 20060248793, Nov. 9, 2006 *
              • Takemoto, J.Y, (2006). Bacterial inhibition by natural products produced by pseudomonads. *
              • Takemoto, J.Y, (2004). Antimicrobial activities of lipodepsipeptide syringopeptins. M.S. Thesis, Utah State University, Biology *
              • Takemoto, J.Y, (2004). Studies of Saccharomyces cerevisiae sphingolipid C4 hydroxylation and IPT1 function and their roles in syringomycin E action. Ph.D. Dissertation, Utah State University, Biology *
              • Takemoto, J.Y, (2001). Method of controlling protozoan infections using syringomycin-family lipodepsipeptides. U.S. Patent No. 6,310,037 *
              • Takemoto, J.Y, (2001). Method of controlling protozoan infections using syringomycin-family lipodepsipeptides. U.S. Patent No. 6,310,037. October 30 *
              • Takemoto, J.Y, (1998). Lipodepsipeptides as antifungal and fungicidal agents. U.S. Patent No. 5,830,855 *
              • Takemoto, J.Y, (1997). Discovery, identification, and evaluation of antifungal compounds produced by Pseudomonas syringae. Ph.D. Dissertation. Utah State University, Logan, UT *
              • Takemoto, J.Y, (1996). CLP-C3A, a New Cyclic Lipodepsipeptide from Pseudomonas Syringae. Thesis, Utah State University, Logan, Utah *
              • Takemoto, J.Y, (1992). Red beet Ca-dependent protein kinases and their role in syringomycin action. PhD. Dissertation, USU, Logan, UT. 135 pp *

              * Has not been peer reviewed

              Scheduled Teaching

              BIOL 4750, 6750 - Topics in Biology (Topic), Summer 2016

              BIOL 4750, 6750 - Topics in Biology, Fall 2015

              BIOL 4750 - Topics in Biology - antimicrobials, Fall 2014

              BIOL 4750/6750 - Topics in Biology - antimicrobials, Fall 2014

              BIOL 6750 - Topics in Biology - synthetic bioproducts research, Spring 2014

              PUBH 4030 - Communicable Disease Control, Fall 2013

              BIOL 6750 - Topics in Biology, Fall 2013

              Bio 5300 - Microbial Physiology, Spring 2013

              BIOL 5300 - Microbial Physiology, Spring 2013

              PUBH 4030 - Communicable Disease Control, Fall 2011

              PUBH 4030 - Communicable Disease Control, Fall 2010


              Graduate Students Mentored

              Kandy Napan, Biological Engineering, August 2010 - June 2015
              Yukie Kawasaki, Biology, January 2009 - December 2014
              Susan Robinson, Biology, September 2012 - June 2014
              Sanjib Shrestha, Biology, August 2008 - January 2014
              Yukie Kawasaki, Biology 2010
              Mekki Bensaci, Biology 2009
              Mekki Bensaci, Biology 2004
              Jolanta Idkowiak-Baldys, Biology 2004
              Rungrach Wangspa, Biology 1999
              Stephen Stock, Biology 1998
              Kevin Sorensen, Biology 1997
              Marianne Kim, Biology 1996
              Domenico DiGiorgio, Biology 1994
              Alberto Fiore, Biology 1994
              Paul Cliften, Biology 1994
              Yuka Suzuki, Biology 1992
              Ron Peterson, Biology 1988
              Kevin Seeley, Biology 1987
              Ashok Bidwai, Biology 1987
              Lei Zhang, Chemistry & Biochemistry 1986
              Donald Menick, Chemistry & Biochemistry 1986
              Brian Stevenson, Biology 1984
              Emily Wilson, Chemistry & Biochemistry 1984
              Kevin Gillies, Biology 1983
              Vikas Padhye, Biology 1983
              Jie Chen, , Biology 1980
              Brent McMillan, Biology 1980
              Khalid Al-Bayatti, Biology 1980