Jon Takemoto

Publications - Abstracts

• Takemoto, J.Y, (2007). Probing the pore geometry of the syringomycin E channel with polyethylene glycols. Biophys. J. *
• Takemoto, J.Y, (2005). Saccharomyces cerevisiae mutants with altered levels of the sphingolipid class of M(IP)2Cs display differential sensitivities to the antifungal plant defensin DmAMP1. Yeast *
• Takemoto, J.Y, (1997). Efficacy of syringomycin E, a new antifungal, in a murine model of vaginal candidiasis. Annual Mtg., Intermountain Branch of the American Society for Microbiology, Abstracts, Vol. 45 *
• Takemoto, J.Y, (1997). Sterol-dependent pore formation of syringomycin E on red blood cell membranes. Eur. Biophys. J. 26:66 *
• Takemoto, J.Y, (1997). Syringomycin E, a new antifungal, in a murine model of vaginal candidiasis: efficacy and local toxicity. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A-041, Miami Beach, FL *
• Takemoto, J.Y, (1997). Cloning and characterization of SYR4, a novel Saccharomyces cerevisiae gene involved in the response to syringomycin. Intrmtn. Branch, Amer. Soc. for Microbiology, Annual Mtg., Abstracts, Vol. 45, Dugway, Utah. April 26 *
• Takemoto, J.Y, (1997). Yeast Cell Binding Studies With Radiolabled Syringomycin. Annual Mtg., Intermountain Branch, American Society for Microbiology, Abstracts, Vol. 45. Dugway, Utah, April 26 *
• Takemoto, J.Y, (1996). CLP-3A, a Novel Antifungal Agent from Pseudomonas Syringae. Abstracts, Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A11 (abstract) *
• Takemoto, J.Y, (1996). Isolation and characterization of novel syringomycin resistant mutants of Saccharomyces cerevisiae. Abstracts, Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A13 *
• Takemoto, J.Y, (1996). Production, purification and in vitro antifimgal activity of syringostatin -A, a new antifungal agent produced by Pseudomonas syringae pv. syringae. Annual Mtg., Intermountain Branch, Amer. Soc. Microbiol. 44:A12 (abstract) *
• Takemoto, J.Y, (1996). Role of secondary metabolites in biological control by Pseudomonas syringae pv. syringae strains ESC-10 and ESC-11. Abstracts, 8th International Congress of Molecular Plant-Microbe Interactions, Knoxville, TN, July 14-20 (abstract) *
• Takemoto, J.Y, (1996). The influence of sterol and phospholipid structure on the properties of syringomycin E-induced channels. Biophys. J. 70(2):Al94 (Abstract) *
• Takemoto, J.Y, (1996). Voltage-gated ion channels formed by syringomycin E in planar lipid bilayers. Biophys. J. 70(2):A194 (Abstract) *
• Takemoto, J.Y, (1995). A novel bioactive lipodepsipeptide produced by Pseudomonas syringae cherry isolate. Abstracts, Ann. Mtg., Intermountain Branch, Amer. Soc. Microbiol. 43:B8 *
• Takemoto, J.Y, (1995). Function of syringomycin response gene, SYR2, in yeast sterol metabolism. Abstracts, 95th Ann. Meet. Amer. Soc. Microbiol. A95 *
• Takemoto, J.Y, (1995). In vitro activity of syringomycin E, a new antifungal produced by Pseudomonas syringae pv. syringae. Abstracts, Ann. Mtg., Intrmntn. Branch Amer. Soc. Microbiol. 43:B10 *
• Takemoto, J.Y, (1995). In vitro antifungal and fungicidal activity of a cyclic lipodepsipeptide, syringomycin E. Abstracts, 35th Interscience Conf. Antimicrob. Agents and Chemotherapy, F103 *
• Takemoto, J.Y, (1995). Role of H2O2 in Syringomycin Action Against Yeast. Abstracts, Ann. Mtg., Intrmntn. Branch, Amer. Soc. Microbiol. 43:B9 *
• Takemoto, J.Y, (1994). Influence of cellular sterol composition on syringomycin inhibition of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A95 *
• Takemoto, J.Y, (1994). Isolation and characterization of novel syringomycin-resistant mutants of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Amer. Soc. Microbiol. A94 *
• Takemoto, J.Y, (1994). SYR2: A Novel Yeast Gene Involved in the Response to Syringomycin. Abs. Ann. Meet. Amer. Soc. Microbiol. A93 *
• Takemoto, J.Y, (1993). Antifungal properties of Pseudomonas syringae pv. syringae strain M1 from wheat seed coat. Abstracts, Ann. Mtg., Inter. Branch, Amer. Soc. Microbiol. 41:A4 *
• Takemoto, J.Y, (1993). Cloning and characterization of SYR2: A novel gene of Saccharomyces cerevisiae involved in the response to syringomycin. Abstracts, Ann. Mtg., Interm. Branch, Amer. Soc. Microbiol. 41:A.5 *
• Takemoto, J.Y, (1993). Identification of gene, SYR1, involved in syringomycin inhibition of Saccharomyces cerevisiae. Abstracts, Ann. Mtg., Interm. Branch, Amer. Soc. Microbiol. 41:A3 *
• Takemoto, J.Y, (1993). Properties of Syringomycin-Resistant Mutants of Saccharomyces Cerevisiae. Abstracts *
• Takemoto, J.Y, (1992). Saccharomyces cerevisiae genes involved in the response to Pseudomonas syringae phytotoxin, syringomycin. Phytopathology 82:1126 *
• Takemoto, J.Y, (1991). Syringomycin-stimulated phosphorylation of the red beet plasma membrane H+-ATPase. Plant Physiol. 96:446 *

Publications - Books & Book Chapters

Book Chapters

• Takemoto, J.Y, (2008). Voltage-dependent ion channels induced by cyclic lipodepsipeptides in planar lipid bilayers: structure, properties, and resemblance to native channels. Advances in Planar Lipid Bilayers and Liposomes, 8.
• Takemoto, J.Y, (2003). The syringomycins: lipodepsipeptide pore formers from plant bacterium, Pseudomonas syringae. Pore Forming Peptides and Protein Toxins
• Takemoto, J.Y, (2000). Analysis of Phosphoinositides in Protein Trafficking. In, Methods: A Companion to Methods in Enzymology
• Takemoto, J.Y, (2000). Assay of the Saccharomyces Cerevisiae Dihydrosphingosine C-4 Hydroxylase. Methods in Enzymol. *
• Takemoto, J.Y, (1992). Bacterial Phytotoxin Syringomycin and Its Action on Host Membranes. IN: Molecular Signals in Plant-Microbe Communications, (ed). D.P.S. Verma. P. 247-260
• Takemoto, J.Y, (1989). Structure of Syringomycin. A Progress Report. p. 359-361. IN: A. Graniti, R.D. Durbin and A. Ballio (eds.), Phytotoxins and Plant Pathogenesis. Springer-Verlag, Berlin-Heidelberg
• Takemoto, J.Y, (1989). Syringomycin Effects on Plasma Membrane Ca+2 Transport, p. 167-175. IN: A. Graniti, R. D. Durbin & A. Ballio (eds.), Phytotoxins & Plant Pathogenesis

* Has not been peer reviewed

Publications - Fact Sheets

* Has not been peer reviewed

Publications - Curriculum

* Has not been peer reviewed

Publications - Journal Articles

Academic Journal

• Shrestha, J., Colman, B., Kawasaki, Y., Nziko, V., Subedi, Y., Takemoto, J.Y, Chang, C.T, (2017). Synthesis and Bioactivity Investigation of Quinone-based Dimeric Cationic Triazolium Amphiphiles Selective against Resistant Fungal and Bacterial Pathogens. Eur. J. Med. Chem., 126, 596.
• Zhang, Q., Alfindee, M.N, Shrestha, J.P, Nziko, Vincent de Paul Nzuwah, , Kawasaki, Y., Peng, X., Takemoto, J.Y, Chang, C.T, (2016). Divergent Synthesis of Three Classes of Antifungal Amphiphilic Kanamycin Derivatives. The Journal of Organic Chemistry, 81:22, 10651-10663.
• Kawasaki, Y., Nischwitz, C., Grilley, M.M, Jones, J., Brown, J.D, Takemoto, J.Y, (2016). Production and Application of Syringomycin E as an Organic Fungicide Seed Protectant against Pythium Damping-off. Journal of Phytopathology, 164:10, 801–810.
• Fosso, M., AlFindee, M.N, Zhang, Q., Nziko Vde, P., Kawasaki, Y., Shrestha, S.K, Bearss, J., Gregory, R., Takemoto, J.Y, Chang, C.W, (2015). Structure-activity relationships for antibacterial to antifungal conversion of kanamycin to amphiphilic analogues. J Org Chem, 80:9, 4398-411.
• Wood, J.L, Miller, C.D, Sims, R.C, Takemoto, J.Y, (2015). Biomass and Phycocyanin Production from Cyanobacteria Dominated Biofilm Reactors Cultured using Oilfield and Natural Gas Extraction Produced Water. Algal Research, 11, 165-168.
• Shrestha, S.K, Grilley, M.M, Anderson, T., Dhiman, C., Oblad, J., Chang, C.T, Sorensen, K.N, Takemoto, J.Y, (2015). In vitro antifungal synergy between amphiphilic aminoglycoside K20 and azoles against Candida species and Cryptococcus neoformans. Med Mycol
• Zhang, Q., Peng, X., Grilley, M.M, Takemoto, J.Y, Chang, C.T, (2015). Using Fluorogenic Probes for the Investigation of Selective Biomass Degradation by Fungi. Green Chem, 17, 1918-1925.
• Napan, K.L, Zhang, S., Anderson, T., Takemoto, J.Y, Zhan, J., (2015). Three enzymes involved in the N-methylation and incorporation of the pradimicin sugar moieties. Biorganic and Medicinal Chemistry Letters, 26:6, 1288-1291. doi: doi.org/10.1016/j.bmcl.2015.01.043
• Shrestha, S.K, Chang, C.T, Meissner, N., Oblad, J., Shrestha, J.P, Sorensen, K.N, Grilley, M.M, Takemoto, J.Y, (2014). Antifungal amphiphilic aminoglycoside K20: bioactivities and mechanism of action. Frontiers in Microbiology, 5:271, 1-12. doi: doi: 10.3389/fmicb.2014.00671
• Chang, C.T, Takemoto, J.Y, (2014). Antifungal amphiphilic aminoglycosides. Med. Chem. Comm., 5, 1048-1057.
• Napan, K., Zhang, S., Morgan, W., Anderson, T., Takemoto, J., Zhan, J., (2014). Synergistic Actions of Tailoring Enzymes in Pradimicin Biosynthesis. ChemBioChem, 5:15, 2289–2296.
• Golo, P.S, Gardner, D., Grilley, M.M, Takemoto, J.Y, Krasnoff, S.B, Pires, M.S, Fernandes, É.K, Bittencourt, V.R, Roberts, D.W, (2014). Production of destruxins from Metarhizium spp. fungi in artificial medium and in endophytically colonized cowpea plants.. PloS one, 9:8, e104946.
• Ito, T., Chen, D., Chang, C.T, Kenmochi, T., Saito, T., Suzuki, S., Takemoto, J.Y, (2013). Mesobiliverdin IXalpha enhances rat pancreatic islet yield and function. Frontiers in Pharmacology, 4:50, doi: DOI10.3389/fphar.2013.00050
• Shrestha, S., Grilley, M.M, Fosso, M.Y, Chang, C.T, Takemoto, J.Y, (2013). Membrane lipid-modulated mechanism of action and non-cytotoxicity of novel fungicide aminoglycolipid FG08. PLoS One, doi: 8:e73843
• Shrestha, S., Grilley, M.M, Fosso, M.Y, Chang, C.T, Takemoto, J.Y, (2013). Membrane Lipid-Modulated Mechanism of Action and Non-Cytotoxicity of Novel Fungicide Aminoglycoside FG08. PloS one, 8:9, e73843.
• Chen, D., Kawasaki, Y., Brown, J., Takemoto, J.Y, (2012). Scalable Bioproduction of Biliverdin IXalpha by Escherichia coli. BMC Biotechnology, 12, 89. doi: DOI:10.1186/1472-6750-12-89
• Bessonov, A., Takemoto, J.Y, Simmel, F., (2012). Probing DNA - lipid membrane interactions with a lipopeptide nanopore.. ACS Nano, 6:4, 3356-3363.
• Napan, K.L, Zeng, J., Takemoto, J.Y, Zhan, J., , (2012). A key cytochrome P450 hydroxylase in pradimicin biosynthesis. Bioorganic and Medicinal Chemistry Letters , 22:1, 606-609. doi: doi:10.1016/j.bmcl.2011.10.075
• Bensaci, M.F, Gurnev, P.A, Bezrukov, S.M, Takemoto, J.Y, (2011). Fungicidal activities and mechanisms of action of Pseudomonas syringae pv. syringae lipodepsipeptide syringopeptins 22A and 25A. Frontiers in Microbiology, 2:216, doi: 10.3389/fmicb.2011.00216
• Chang, C.T, Fosso, M., Kawasaki, Y., Bensaci, M., Evans, C.K, Wang, J.H, Shrestha, S., Takemoto, J.Y, , (2010). Antibacterial to antifungal conversion of neamine aminoglycoisodes through alkyl modification. Strategy for reviving an old drug into agrofungicides. J. Antibiotics, 63, 667-672.
• Takemoto, J.Y, (2010). Inhibition of fungi from diseased grape by syringomycin E-rhamnolipid mixture.. Amer. J. Enol. Viti., 61, 120-124.
• Takemoto, J.Y, (2009). Synthesis and combinational antibacterial study of 5-modified neomycin. J. Antibiotics, 62, 539-544.
• Takemoto, J.Y, (2008). Bioactive lipopeptides of ice nucleating snow bacterium Pseudomonas syringae strain 31R1. FEMS Microbiol. Lett., 286, 158-165.
• Takemoto, J.Y, (2008). Altering channel forming activity of syringomycin E via membrane dipole potential. Langmuir, 24, 2987-2991.
• Takemoto, J.Y, (2007). Sonication-assisted library synthesis of oxazolidine carbohydrate conjugates. J. Combinatorial Chem., 9, 17-19.
• Takemoto, J.Y, (2007). Syringopeptin SP25A-mediated killing of Gram-positive bacteria and role of teichoic acid D-alanylation. FEMS Microbiol Lett, 268, 106-111.
• Bessonov, A.N, Schagina, L.V, Turoverov, K.K, Kumetsova, I., Takemoto, J.Y, Malev, V.V, (2006). Influence of cooperative adsorption of macromolecules on the channel-forming activity of syringomycin E in lipid bilayers. Biologicheskie Membrany, 23:3, 261-270.
• Takemoto, J.Y, (2006). Actin and amphiphilic polymers influence on channel formation by syringomycin E in lipid bilayers. Eur J. Biophys., 35, 382-392.
• Thevissen, K., Idkowiak-Baldys, J., Im, Y.J, Takemoto, J.Y, Francois, I. E. J. A., , Ferket, K.K, Takemoto, J.Y, Meert, E.M, Winderickx, J., Roosen, J., Cammue, B.P, (2005). SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. FEBS Letters, 579:9, 1973-1977.
• Thevissen, K., Idkowiak-Baldys, J., Im, Y.J, Takemoto, J.Y, Francois, I. E. J. A., , Ferket, K.K, Takemoto, J.Y, Meert, E.M, Winderickx, J., Roosen, J., Cammue, B.P, (2005). SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. FEBS Letters, 579:9, 1973-1977.
• Takemoto, J.Y, (2005). Voltage-dependent synchronization of gating of syringomycin E ion channel. FEBS Letters, 579, 5675-5679.
• Takemoto, J.Y, (2005). Novel cyclic lipodepsipeptide from Pseudomonas syringae pv. lachrymans strain 508 and syringopeptin antimicrobial activities. Antimicrob. Agents Chemother., 49, 5037-5045.
• Takemoto, J.Y, (2005). SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis. FEBS Lett., 579, 5675-5679.
• Takemoto, J.Y, (2005). Sphingolipids influence the sensitivity of lipid bilayers to fungicide syringomycin E.. J. Bioenerg. Biomemb., 37, 339-348.
• Takemoto, J.Y, (2004). Application of the synthetic aminosugars for glycodiversification: synthesis and antimicrobial studies of pyranmycin.. J. Org. Chem., 69, 1513-1523.
• Takemoto, J.Y, (2004). Sphingolipid C4 hydroxylation influences properties of yeast detergent-insoluble glycolipid-enriched membranes. FEBS Lett, 569, 272-276.
• Takemoto, J.Y, (2004). Synthesis of trehalose-based compounds and study of their antibacterial activity against Mycobacterium smegmatis. Bioorg. Med. Chem., 12, 6397-6413.
• Idkowiak-Baldys, J., Takemoto, J.Y, Grilley, M.M, (2003). Structure– function studies of yeast C-4 sphingolipid long chain base hydroxylase. Biochimica et Biophysica Acta (BBA)/Biomembranes, 1618, 17-24.
• Takemoto, J.Y, (2003). DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae. FEMS Microbiol Letters, 223, 199-203.
• Takemoto, J.Y, (2003). Effective gating charge of ion channels induced by toxin syringomycin E in lipid bilayers. Bioelectrochem., 5776, 7-Jan.
• Takemoto, J.Y, (2003). IPT1-independent sphingolipid biosynthesis and yeast inhibition by syringomycin E and plant defensin DmAMP1. FEMS Microbiol. Lett., 11016, 5-Jan.
• Takemoto, J.Y, (2003). Structure-function studies of yeast C-4 sphingolipid long chain base hydroxylase. Biochim. Biophys. Acta, 1618, 17-24.
• Takemoto, J.Y, (2002). Syringomycin E channel: a lipidic pore stabilized by lipopeptide. Biophys. J., 82, 1985-1994.
• Takemoto, J.Y, (2002). Syringotoxin pore formation and inactivation in human red blood cells and model bilayer lipid membranes. Biochim. Biophys. Acta, 1567, 143-149.
• Takemoto, J.Y, (2002). The synthesis of L-aminosugars and the studies of L-pyranoses on ring III of pyranmycins. Organic Lett., 4, 3997-4000.
• Takemoto, J.Y, (2001). Spatial charge distribution effects in the conductance of syringomycin E ion channels formed in lipid bilayers. Biological Membranes, 18, 145-153.
• Takemoto, J.Y, (2000). Effect of temperature on the formation and inactivation of syringomycin pores in red blood cells and bimolecular lipid membranes. Biochim. Biophys. Acta, 1466, 79-86.
• Takemoto, J.Y, (2000). Kinetics of opening-closure of syringomycin E channels formed in lipid bilayers. Biological Membranes, 17, 653-665.
• Takemoto, J.Y, (2000). Membrane permeabilizing activities of cyclic lipodepsipeptides, syringopeptin 22A and syringomycin E from Pseudomonas syringae pv. syringae in human red blood cells and in bilayer lipid membranes. Bioelectrochemistry, 52, 161-167.
• Takemoto, J.Y, (2000). Requirement of sphingolipid alpha hydroxylation for fungicidal action of syringomycin E. FEBS Letters, 478, 26-28.
• Takemoto, J.Y, (2000). Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very long fatty acids and mannose and phosphoinositol containing head groups. Antimicrob. Agents Chemother., 44, 1174-1180.
• Grilley, M.M, Takemoto, J.Y, (2000). Assay of the Saccharomyces cerevisiae dihydrosphingosine C-4 hydroxylase.. Methods in enzymology, 311, 9-14.
• Takemoto, J.Y, (1999). Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. J. Biol. Chem., 274, 34294-34300.
• Takemoto, J.Y, (1999). Fungal Lethality, Binding, and Cytotoxicity of Syringomycin E. Antimicrob.. Agents Chemo., 43, 371-373.
• Takemoto, J.Y, (1999). SEC14-dependent secretion in Saccharomyces cerevisiae: non-dependence on sphingolipid-coupled diacylglycerol synthesis. J. Biol. Chem., 274, 12979-1298.
• Takemoto, J.Y, (1998). Cluster organization of ion channels formed by the antibiotic syringomycin E in bilayer lipid membranes. Biophys. J. 74:2918-2925
• Takemoto, J.Y, (1998). Cyclic lipodepsinonapeptide producing strains of Pseudomonas syringae pv. syringae: PCR detection and similarity. Appl. Environmental Microbiol. 64:226-230
• Takemoto, J.Y, (1998). Efficacy of Syringomycin E in a Murine Model of Vaginal Candidiasis. J. Antibiotics 51:743-749
• Takemoto, J.Y, (1998). Membrane sterol composition modulates the pore forming activity of syringomycin E in human red blood cells. Biochim. Biophys. Acta 1373:163-169
• Takemoto, J.Y, (1998). Role of ergosterol in growth inhibition of Saccharomyces cerevisiae by syringomycin E. FEMS Microbiol. 167:215-220
• Takemoto, J.Y, (1998). Syringomycin action gene SYR2 is essential for sphingoplipid 4-hydroxylation in Saccharomyces cerevisiae. J. Biol. Chem. 273:11062-11068
• Takemoto, J.Y, (1998). Syringomycin E produced by biological control agents controls green mold on lemons. Biological Control 12(2):89-95
• Grilley, M.M, Stock, S.D, Dickson, R.C, Lester, R.L, Takemoto, J.Y, (1998). Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae.. The Journal of biological chemistry, 273:18, 11062-8.
• Takemoto, J.Y, (1997). The effect of sterols on the sensitivity of membrane to the channel forming antifungal antibiotic, syringomycin E. Biochim. Biophys. Acta 1324:102-110
• Takemoto, J.Y, (1996). In vitro antifungal and fungicidal activities and erythrocyte toxicities of cyclic lipodepsinonapeptides produced by Pseudomonas syringae pv.syringae. Antimicrob. Agents Chemother. 40:2710-2713
• Takemoto, J.Y, (1996). Phytotoxin production by Pseudomonas syringae pv. syringae: syringopeptin production by syr mutants defective in biosynthesis or secretion of syringomycin. FEMS Microbiol. Lett. 138:35-39
• Takemoto, J.Y, (1996). Properties of voltage-gated ion channels formed by syringomycin E in planar lipid bilayers. J. Membrane Biol. 149:41-47
• Takemoto, J.Y, (1996). Suppression of mitogen-induced lymphocyte proliferation by syringmycin-E. FEMS Immunol. Med. Microbiol. 15:177-179
• Takemoto, J.Y, (1996). SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae. Microbiology 147:477-484
• Takemoto, J.Y, (1996). Syringopeptins, Pseudomonas syringae pv. syringae phytotoxins, resemble syringomycin in closing stomata. Plant Pathol. 45:564-571
• Takemoto, J.Y, (1995). Nonpathogenic Pseudomonas syringae wheat isolate M1 produces lipodepsipeptides syringomycin and syringopeptin. FEMS Microbiol. Lett. 131:63-67
• Takemoto, J.Y, (1995). Other Lipopeptides. Science 267:605
• Takemoto, J.Y, (1995). Structural Analysis of New Syringopeptins by Tandem Mass Spectroscopy. Biosci. Biotech. Biochem. 59:1374-1376
• Takemoto, J.Y, (1995). The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae. Biosci. Biotech. Biochem. 59:482-486
• Takemoto, J.Y, (1994). Identification and analysis of the Saccharomycs cerevisae SYR1 gene reveals that ergosterolis is involved in the action of Syringomycin. Microbiology 140:353-359
• Takemoto, J.Y, (1994). Stereochemical structure of syringomycin, a phytotoxic metabolite of Pseudomonas syringae pv. syringae. Natural Prod. Lett. 4:159-164
• Takemoto, J.Y, (1993). Protection by sterols against the cytotoxicity of syringomycin in the yeast Saccharomyces cerevisiae. J. Gen. Microbiol. 139:2323-2327
• Takemoto, J.Y, (1993). Yeast genes involved in growth inhibition by Pseudomonas syringae pv. syringae syringomycin family lipodepsipeptides. FEMS Microbiol. Lett. 114:339-342
• Takemoto, J.Y, (1992). Structures and stereochemistry of three phytotoxins: syringomycin, syringotoxin and syringostatin produced by Pseudomonas syringae pv. syringae. J. Chem. Soc. Perkin Trans. 1:1149-1157
• Takemoto, J.Y, (1992). Syringomycin-stimulated phosphorylation of the plasma membrane H+-ATPase from red beet storage tissue. Plant Physiol. 99:1314-1320
• Takemoto, J.Y, (1991). Mechanism of Action of the Phytotoxin Syringomycin. A resistant mutant of Saccharomyces cerevisiae reveals an involvement of Ca2+ transport. J. Gen. Microbiol. 137:653-659. J. Gen. Microbiol. 136:653-659
• Takemoto, J.Y, (1990). Structure of phytotoxin syringomycin produced by a sugar cane isolate of Pseudomonas pv. syringae. Tetrahedron Lett. 31:1589-1592
• Takemoto, J.Y, (1989). 31-P-NMR evidence for cytoplasmic acidification and phosphate extrusion in syringomycin-treated cells of Rhodotorula pilimanae. Biochem. Biophy. Acta 1010:325-329
• Takemoto, J.Y, (1989). Syringomycin Stimulation of Potassium Efflux by Yeast Cells. Biochim. Biophys. Acta 987:171-173
• Takemoto, J.Y, (1989). Syringomycin, a Bacterial Phytotoxin, Closes Stomata. Plant Physiol. 90:1435-1439
• Takemoto, J.Y, (1989). The Structure of Syringomycins A, E and G. FEBS Letter 255:27-31
• Tadros, M.H, Frank, R., Takemoto, J., Drews, G., (1988). Localization of Reaction Center and B800-850 Antenna Pigment Proteins in Membranes of Rhodobacter-Sphaeroides. Journal of Bacteriology, 170:6, 2758-2762.
• Reinbold, R.S, Takemoto, J.Y, (1988). Use of Swiss Cheese Whey Permeate by Kluyveromyces-Fragilis and Mixed Culture of Rhodopseudomonas-Sphaeroides and Bacillus-Megaterium. Journal of Dairy Science, 71:7, 1799-1802.
• Reinbold, R., Takemoto, J.Y, (1988). Use of Swiss Cheese Whey Permeate by Kluyveromyces fragilis and Mixed Culture of Rhodopseudomonas sphaeroides and Bacillus megaterium. Journal of Dairy Science, 71:7, 1799-1802.
• Tadros, M.H, Frank, R., Doerge, B., Gad'on, N., Takemoto, J.Y, Drews, G., (1987). Orientation of the B800-850, B870, and reaction center polypeptides on the cytoplasmic and periplasmic surfaces of Rhodobacter capsulata membranes. Biochemistry, 26:24, 7680-7687.
• Bidwai, A.P, Takemoto, J.Y, (1987). Bacterial Phytotoxin, Syringomycin, Induces a Protein Kinase-Mediated Phosphorylation of Red Beet Plasma-Membrane Polypeptides. Proceedings of the National Academy of Sciences of the United States of America, 84:19, 6755-6759.
• Bidwai, A.P, Takemoto, J.Y, (1987). Bacterial Phytotoxin, Syringomycin, Stimulates a Protein-Kinase Mediated Phosphorylation of Red Beet Plasma-Membrane Polypeptides. Journal of Cellular Biochemistry, 93-93.
• Lei, Z., Takemoto, J.Y, (1987). Effects of Pseudomonas-Syringae Phytotoxin, Syringomycin, on Plasma-Membrane Functions of Rhodotorula-Pilimanae. Phytopathology, 77:2, 297-303.
• Reidl, H.H, Takemoto, J.Y, (1987). Mechanism of Action of Bacterial Phytotoxin, Syringomycin - Simultaneous Measurement of Early Responses in Yeast and Maize. Biochimica Et Biophysica Acta, 898:1, 59-69.
• Bidwai, A.P, Bachmann, R.C, Takemoto, J.Y, (1987). Mechanism of Action of Pseudomonas-Syringae Phytotoxin, Syringomycin - Stimulation of Red Beet Plasma-Membrane Atpase Activity. Plant Physiology, 83:1, 39-43.
• Tadros, M.H, Frank, R., Dorge, B., Gadon, N., Takemoto, J.Y, Drews, G., (1987). Orientation of the B800-850, B870, and Reaction Center Polypeptides on the Cytoplasmic and Periplasmic Surfaces of Rhodobacter-Capsulatus Membranes. Biochemistry, 26:24, 7680-7687.
• Takemoto, J.Y, Peterson, R.L, Tadros, M.H, Drews, G., (1987). Transverse Membrane Topography of the B875 Light-Harvesting Polypeptides of Wild-Type Rhodobacter-Sphaeroides. Journal of Bacteriology, 169:10, 4731-4736.
• Bidwai, A.P, Takemoto, J.Y, (1987). Bacterial phytotoxin, syringomycin, induces a protein kinase-mediated phosphorylation of red beet plasma membrane polypeptides. Proceedings of the National Academy of Sciences, 84:19, 6755-6759.
• Reidl, H., Takemoto, J.Y, (1987). Mechanism of action of bacterial phytotoxin, syringomycin. Simultaneous measurement of early responses in yeast and maize. Biochimica et Biophysica Acta (BBA) - Biomembranes, 898:1, 59-69.
• Zhang, L., Takemoto, J.Y, (1986). Mechanism of action of Pseudomonas syringae phytotoxin, syringomycin. Interaction with the plasma membrane of wild-type and respiratory-deficient strains of Saccharomyces cerevisiae. Biochimica et Biophysica Acta (BBA) - Biomembranes, 861, 201-204.
• Takemoto, J.Y, Schonhardt, T., Golecki, J.R, Drews, G., (1985). Fusion of Liposomes and Chromatophores of Rhodopseudomonas-Capsulata - Effect on Photosynthetic Energy-Transfer between B875 and Reaction Center Complexes. Journal of Bacteriology, 162:3, 1126-1134.
• Wilson, E., Farley, T.M, Takemoto, J.Y, (1985). Photoaffinity-Labeling of an Antimycin-Binding Site in Rhodopseudomonas-Sphaeroides. Journal of Biological Chemistry, 260:18, 288-292.
• Zhang, L., Takemoto, J.Y, (1985). Pseudomonad phytotoxin, syringomycin stimulates the plasma-membrane ATPase of Rhodotorula pilimanae. Phytopathology, 75:11, 1381-1381.
• Takemoto, J.Y, (1984). Basic Research in Photosynthesis. Utah Science, 45:1, 1-3.
• Bachmann, R.C, Takemoto, J.Y, (1983). Near-Neighbor Relationships of the Photosynthetic Reaction Center Polypeptides of Rhodopseudomonas-Sphaeroides. Biochemistry International, 7:2, 137-145.
• Bachmann, R.C, Tadros, M.H, Oelze, J., Takemoto, J.Y, (1983). Purification and Characterization of the B875 Light-Harvesting Complex of Rhodopseudomonas-Sphaeroides. Biochemistry International, 7:5, 629-634.
• Peters, J., Takemoto, J.Y, Drews, G., (1983). Spatial relationships between the photochemical-reaction Center and the Light-Harvesting Complexes in the Membrane of Rhodopseudomonas-Capsulata. Biochemistry, 22:24, 5660-5667.
• Takemoto, J.Y, Peters, J., Drews, G., (1982). Crosslinking of Photosynthetic Membrane Polypeptides of Rhodopseudomonas-Capsulata. FEBS Letters, 142:2, 227-230.
• Gillies, K., Takemoto, J.Y, (1981). Absence of Reaction Center Subunit H in Bacteriochlorophyll Mutant 8-17 of Rhodopseudomonas-Sphaeroides. Fems Microbiology Letters, 12:1, 7-10.
• Chen, J., Miller, G.W, Takemoto, J.Y, (1981). Biosynthesis of delta-aminolevulinic-acid in Rhodopseudomonas-Sphaeroides. Archives of Biochemistry and Biophysics, 208:1, 221-228.
• Bachmann, R.C, Gillies, K., Takemoto, J.Y, (1981). Membrane topography of the photosynthetic reaction center polypeptides of Rhodopseudomonas sphaeroides. Biochemistry, 20:16, 4590-4596.
• Al-Bayatti, K., Takemoto, J.Y, (1981). Phospholipid Topography of the Photosynthetic Membrane of Rhodopseudomonas-Sphaeroides. Biochemistry, 20:19, 5489-5495.
• Kendalltobias, M., Takemoto, J.Y, (1981). Simple, Compact, and Inexpensive Light-Dark Attachment for Scanning Spectrophotometers. Rev Sci Instru, 52:1, 141-142.
• Gillies, K., Takemoto, J.Y, (1981). Absence of reaction center subunit H in bacteriochlorophyll mutant 8-17 ofRhodopseudomonas sphaeroides. FEMS Microbiology Letters, 12:1, 7-10.
• Takemoto, J.Y, Bachmann, R.C, (1979). Orientation of chromatophores and spheroplast-derived membrane vesicles of Rhodopseudomonas sphaeroides: Analysis by localization of enzyme activities. Archives of Biochemistry and Biophysics, 195:2, 526-534.
• Lommen, M.A, Takemoto, J.Y, (1978). Comparison, by Freeze-Fracture Electron-Microscopy, of Chromatophores, Spheroplast-Derived Membrane-Vesicles, and Whole Cells of Rhodopseudomonas-Sphaeroides. Journal of Bacteriology, 136:2, 730-741.
• Lommen, M.A, Takemoto, J.Y, (1978). Ultrastructure of Carotenoid Mutant Strain R-26 of Rhodopseudomonas-Sphaeroides. Archives of Microbiology, 118:3, 305-308.
• Takemoto, J.Y, Huang Kao, M.Y, (1977). Effects of Incident Light Levels on Photosynthetic Membrane Polypeptide Composition and Assembly in Rhodopseudomonas-Sphaeroides. Journal of Bacteriology, 129:2, 1102-1109.
• Takemoto, J.Y, Bogorad, L., (1975). Subunits of phycoerythrin from Fremyella diplosiphon - chemical and Immunochemical Characterization. Biochemistry, 14:6, 1211-1216.
• Takemoto, J.Y, Lascelles, J., (1974). Function of membrane proteins coupled to bacteriochlorophyll synthesis. Archives of Biochemistry and Biophysics, 163:2, 507-514.
• Takemoto, J.Y, (1974). Kinetics of photosynthetic membrane protein assembly in Rhodopseudomonas spheroides. Archives of Biochemistry and Biophysics, 163:2, 515-520.

* Has not been peer reviewed

Publications - Literary Journal

* Has not been peer reviewed

Publications - MultiMedia

* Has not been peer reviewed

Publications - Technical Reports

* Has not been peer reviewed

Publications - Translations & Transcripts

Publications - Other

Other

• Takemoto, J.Y, Chen, D., Chang, C.T, Jonathan, W.L, (2015). Therapeutic mesobiliverdin IXalpha compositions and associated methods, Patent assigned, US9119842 B2. United States Patent Office
• Takemoto, J.Y, Chang, C.W, Shrestha, S.K, Grilley, M.M, (2014). Aminoglycoside and Azole Compositions and Methods. Google Patents
• Takemoto, J.Y, Chen, D., Chang, C.T, Jonathan, W.L, (2014). Therapeutic compositions and associated methods. World Intellectual Property Organization
• Takemoto, J.Y, Chen, D., (2013). Biliverdin from Non-Animal Source, U.S. Patent 8,455,222,B2. U.S. Patent and Trademark Office
• Takemoto, J.Y, (2009). New synthetic antifungal agents. USU Technology Notification/Invention Disclosure *
• Takemoto, J.Y, (2009). Enhanced bioproduction of biliverdin-IX alpha. Provisional Patent Application 61258126 *
• Takemoto, J.Y, (2009). Novel antimicrobial aminoglycosides: synthesis and use as antifungals. PCT Utility Patent Application 61258126 *
• Takemoto, J.Y, (2007). Antimycotic rhamnolipid compositions and related methods of use. U.S.Patent, application serial no. 11/351,572, Feb. 2, 2006 *
• Takemoto, J.Y, (2007). Method for making fungi compatible artificial snow. U.S. Patent application serial no 20060248793, Nov. 9, 2006 *
• Takemoto, J.Y, (2006). Bacterial inhibition by natural products produced by pseudomonads. *
• Takemoto, J.Y, (2004). Antimicrobial activities of lipodepsipeptide syringopeptins. M.S. Thesis, Utah State University, Biology *
• Takemoto, J.Y, (2004). Studies of Saccharomyces cerevisiae sphingolipid C4 hydroxylation and IPT1 function and their roles in syringomycin E action. Ph.D. Dissertation, Utah State University, Biology *
• Takemoto, J.Y, (2001). Method of controlling protozoan infections using syringomycin-family lipodepsipeptides. U.S. Patent No. 6,310,037 *
• Takemoto, J.Y, (2001). Method of controlling protozoan infections using syringomycin-family lipodepsipeptides. U.S. Patent No. 6,310,037. October 30 *
• Takemoto, J.Y, (1998). Lipodepsipeptides as antifungal and fungicidal agents. U.S. Patent No. 5,830,855 *
• Takemoto, J.Y, (1997). Discovery, identification, and evaluation of antifungal compounds produced by Pseudomonas syringae. Ph.D. Dissertation. Utah State University, Logan, UT *
• Takemoto, J.Y, (1996). CLP-C3A, a New Cyclic Lipodepsipeptide from Pseudomonas Syringae. Thesis, Utah State University, Logan, Utah *
• Takemoto, J.Y, (1992). Red beet Ca-dependent protein kinases and their role in syringomycin action. PhD. Dissertation, USU, Logan, UT. 135 pp *

* Has not been peer reviewed

Scheduled Teaching

Graduate Students Mentored