Findings:
With our collaborators, we discovered that phosphoinositide signaling systems are involved in the process of breast cancer metastasis, and that metastasis suppressor genes reduce phosphoinositide-mediated processes thus converting metastatic cells to non-metastatic cells.

Directions:
We continue to study the interatction between metastasis suppressor genes and phosphoinositide-medicated celluar processes.

The DeWald lab is collaborating with engineers in an effort to do predictive modeling of mammalian cell signal transduction pathways.